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title: ABclonal Knowledge Base
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[](https://blog.abclonal.com/blog/the-structural-basis-of-nlrp3-inflammasome-assembly-and-activation)
Aug 1, 2026, 9:00:00 AM by [Team - ABclonal](https://blog.abclonal.com/blog/author/team-abclonal-1)
## [The Structural Basis of NLRP3 Inflammasome Assembly and Activation](https://blog.abclonal.com/blog/the-structural-basis-of-nlrp3-inflammasome-assembly-and-activation)
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[](https://blog.abclonal.com/blog/the-impact-of-negative-emotional-states-on-tumor-immune-evasion)
Jul 5, 2026, 10:26:19 PM by [Team - ABclonal](https://blog.abclonal.com/blog/author/team-abclonal-1)
## [The Impact of Negative Emotional States on Tumor Immune Evasion](https://blog.abclonal.com/blog/the-impact-of-negative-emotional-states-on-tumor-immune-evasion)
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[](https://blog.abclonal.com/blog/optimizing-if-outcomes-through-rational-antibody-selection)
Jun 1, 2026, 2:52:12 PM by [Team - ABclonal](https://blog.abclonal.com/blog/author/team-abclonal-1)
## [Optimizing IF Outcomes Through Rational Antibody Selection](https://blog.abclonal.com/blog/optimizing-if-outcomes-through-rational-antibody-selection)
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[](https://blog.abclonal.com/blog/abclonal-x-ycharos-setting-the-gold-standard-in-antibody-characterization)
Jan 23, 2025, 12:42:04 PM by [Team - ABclonal](https://blog.abclonal.com/blog/author/team-abclonal-1)
## [ABclonal x YCharOS: Setting the Gold Standard in Antibody Characterization](https://blog.abclonal.com/blog/abclonal-x-ycharos-setting-the-gold-standard-in-antibody-characterization)
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[](https://blog.abclonal.com/blog/research-methods-for-cell-pyroptosis)
Dec 30, 2024, 10:17:16 AM by [Team ABclonal](https://blog.abclonal.com/blog/author/team-abclonal)
## [Research Methods for Cell Pyroptosis](https://blog.abclonal.com/blog/research-methods-for-cell-pyroptosis)
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Detailed Guideline on Pyroptosis Research
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[](https://blog.abclonal.com/blog/gasdermins-the-gatekeepers-of-pyroptosis)
Nov 25, 2024, 3:19:54 PM by [Team ABclonal](https://blog.abclonal.com/blog/author/team-abclonal)
## [Gasdermins – the "Gatekeepers" of Pyroptosis](https://blog.abclonal.com/blog/gasdermins-the-gatekeepers-of-pyroptosis)
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It is evident that the gasdermin family is central to pyroptosis. This is because the gasdermin family members are the executioners of pyroptosis, and their pore-forming function is a necessary condition for pyroptosis to occur. This family generally includes a cytotoxic N-terminal domain and a C-terminal inhibitory domain. After cleavage, the N-terminal domain is released and can assemble into pores in the membrane. Gasdermin pores disrupt the integrity of the cell membrane, leading to inflammatory cell death, with cell contents, including inflammatory cytokines, being released into the extracellular space.
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