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title: ABclonal Knowledge Base | chromatin
description: chromatin |
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[](https://blog.abclonal.com/blog/cuttag-an-alternative-to-chip)
Aug 15, 2022, 11:37:47 AM by [Kin Leung](https://blog.abclonal.com/blog/author/kin-leung)
## [CUT&Tag: An Alternative to Chromatin Immunoprecipitation](https://blog.abclonal.com/blog/cuttag-an-alternative-to-chip)
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The arguably most fun thing about science is when your supervisor tells you to just do Experiment X to test hypothesis, but then they kind of forget to tell you how complicated the techniques are to perform that experiment, not to mention all the optimization you would need to do. I personally have never done a chromatin immunoprecipitation (ChIP), and since I wasn’t in genomics, the most sequencing I ever did was setting up quick reactions for the core facility to tell me that my gene constructs were correctly built. ChIP does sound rather simple when explained in class, but when you read up on the protocols,1 there are some limitations to what ChIP can do, especially given the large amount of starting material you need for the typical experiment. Luckily, in recent years, scientists have started to use an alternative technique called Cleavage Under Targets and Tagmentation, or CUT&Tag, which ABclonal is pleased to support through our antibody reagents.
[Read More](https://blog.abclonal.com/blog/cuttag-an-alternative-to-chip)
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