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title: ABclonal Knowledge Base | Housekeeping Protein
description: Housekeeping Protein |
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[](https://blog.abclonal.com/blog/high-dilution-gapdh-monoclonal-antibody)
Dec 4, 2018, 10:35:13 AM by [Panyue (Penny) Hao](https://blog.abclonal.com/blog/author/panyue-penny-hao)
## [High-Dilution GAPDH Monoclonal Antibody](https://blog.abclonal.com/blog/high-dilution-gapdh-monoclonal-antibody)
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The glyceraldehyde-3-phosphate dehydrogenase, or GAPDH for short), is a multifunctional, indispensable enzyme found in all cells. The generally known function of GAPDH is to assist in carbohydrate metabolism as a key player in glycolysis, but there are studies demonstrating its role in the nucleus as well.
GAPDH is a constitutively expressed housekeeping protein, and GAPDH mRNA levels and protein levels are often used as loading controls in experiments that quantify target-specific expression changes. Recent studies have elucidated the role of [GAPDH in apoptosis](https://www.nature.com/articles/1210074), gene expression through its possible activities as a transcription factor, and nuclear transport. As both a metabolic protein as well as one that might play a role in cytoskeletal reorganization, GAPDH activity is intricately tied to tumorigenesis. GAPDH may also play a role in neurodegenerative diseases such as Huntington's disease and Alzheimer's disease. Therefore, although many researchers do use GAPDH as a control, this protein needs to be appreciated for its myriad other functions as well!
ABclonal Technology's GAPDH recombinant rabbit monoclonal antibody is a human-specific antibody that can be used with a high dilution ratio of 1:2560000. As a highly-stable antibody product, this means that you can perform numerous Western blotting experiments over a long period of time using a small quantity of antibody, as well as in other experiments to study the functions of GAPDH. Take advantage of this robust, cost-effective antibody product in your research today!
[Read More](https://blog.abclonal.com/blog/high-dilution-gapdh-monoclonal-antibody)
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