--- title: ABclonal Knowledge Base | Organoids description: Organoids | --- [![](https://img.abclonal.com/abclonal/Public/Images/25121homepage-logo.png)](https://blog.abclonal.com/) [\[fa icon="user"\]](https://abclonal.com/user/login) [\[fa icon="shopping-cart"\]](https://abclonal.com/shoppingcart) - [Products & Services](https://abclonal.com/catalog-antibodies?id=1) - [Publications](https://abclonal.com/learning/publications) - [Resources](https://abclonal.com/featured-topics) - [![](https://img.abclonal.com/abclonal/Public/Images/25121homepage-logo.png)](https://abclonal.com) - [Promotion](https://abclonal.com/sales/promos) - [Partnership](https://abclonal.com/partner/partnership) - [Company](https://abclonal.com/company/aboutUs) [\[fa icon="user"\]](https://abclonal.com/user/login) [\[fa icon="shopping-cart"\]](https://abclonal.com/shoppingcart) Blogs This is a search field with an auto-suggest feature attached. - There are no suggestions because the search field is empty. - [![Share on facebook](https://blog.abclonal.com/hs-fs/hubfs/hs_marketplace_assets/modules/Social%20Sharing/79/facebook-color.png?width=24&name=facebook-color.png)](http://www.facebook.com/share.php?u=https://blog.abclonal.com/blog/topic/organoids&utm_medium=social&utm_source=facebook) - [![Share on linkedin](https://blog.abclonal.com/hs-fs/hubfs/hs_marketplace_assets/modules/Social%20Sharing/79/linkedin-color.png?width=24&name=linkedin-color.png)](http://www.linkedin.com/shareArticle?mini=true&url=https://blog.abclonal.com/blog/topic/organoids&utm_medium=social&utm_source=linkedin) - [![Share on twitter](https://blog.abclonal.com/hs-fs/hubfs/hs_marketplace_assets/modules/Social%20Sharing/79/twitter-color.png?width=24&name=twitter-color.png)](https://twitter.com/intent/tweet?original_referer=https://blog.abclonal.com/blog/topic/organoids&utm_medium=social&utm_source=twitter&url=https://blog.abclonal.com/blog/topic/organoids&utm_medium=social&utm_source=twitter&source=tweetbutton&text=) - [![Share on google_plus](https://blog.abclonal.com/hs-fs/hubfs/hs_marketplace_assets/modules/Social%20Sharing/79/google_plus-color.png?width=24&name=google_plus-color.png)](https://plus.google.com/share?url=https://blog.abclonal.com/blog/topic/organoids&utm_medium=social&utm_source=google_plus) [![](https://img.abclonal.com/abclonal/Public/Images/0914shutterstock_07.jpg) WHAT'S HOT IN LIFE](https://blog.abclonal.com/blog/topic/whats-hot) [![](https://img.abclonal.com/abclonal/Public/Images/0914shutterstock_06.jpg) #LABLIFE](https://blog.abclonal.com/blog/topic/lab-life) [![](https://img.abclonal.com/abclonal/Public/Images/0914shutterstock_05.jpg) ABCLONAL](https://blog.abclonal.com/blog/topic/abclonal-news) [![cancer](https://blog.abclonal.com/hubfs/cancer.jpg)](https://blog.abclonal.com/blog/the-next-cancer-model) Jan 21, 2019, 7:46:19 PM       by [Michele Mei](https://blog.abclonal.com/blog/author/michele-mei) ## [The Next Cancer Model](https://blog.abclonal.com/blog/the-next-cancer-model) - [Tweet](https://twitter.com/share) ## The Problem with Cancer Models Very few cancer drugs succeed in clinical trials, despite showing promise in the lab. Treatments that may work on animal models, cell lines, or even patient-derived xenografts often do not have the same efficacy in patients. The underlying reason is tumor environments within the human body are far more complex than in research models. For example, the tissue structure (histological complexity) and [genetic heterogeneity](http://dmm.biologists.org/content/11/11/dmm037366) of an animal model is different than that of humans. Even cell lines and patient-derived xenografts, which are human-derived, have their own pitfalls such as genetic mutations and animal-specific tumor evolution, respectively. Due to the inability to reproduce human tumor environments, many drugs fail clinical trials after lengthy and costly development. 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