STAT5B belongs to the STAT (signal transducer and activator of transcription) protein family, a group of latent cytosolic transcription factors activated by Janus kinase (JAK) tyrosine kinases. The JAK-STAT signaling pathway is responsible for many important biological processes including cell proliferation, differentiation, apoptosis, and is also involved in the modulation of a variety of cytokines to control the immune response.
Previous studies have shown that STAT5B is involved in T cell receptor-mediated signaling, adult mammary gland development, and sexual dimorphism of liver gene expression. When activated, STAT5B interacts with the activated receptor through its Src-homology 2 (SH2) domain, and is subsequently phosphorylated by JAK. Subsequently, STAT5B homodimers and STAT5A/STAT5B heterodimers can translocate to the nucleus to regulate gene transcription through its DNA-binding domain recognizing specific sequences, including the interferon gamma (IFN-γ) activation sequence. 1
As an original manufacturer, ABclonal uses proven methodologies to produce consistently high-quality antibodies against your desired targets, including STAT5B. Our STAT5B rabbit monoclonal antibody is validated with knockout cell lines to demonstrate specificity, and has been corroborated by independent characterization. Feel free to contact us at service@abclonal.com or visit our website to explore our vast catalog of antibody reagents to accelerate your research!
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