---
title: "Featured Product Weekly: DNA Methyltransferase Antibody"
description: DNA methyltransferases (DNMTs) catalyze and maintain DNA methylation for epigenetic regulation of gene expression and genomic imprinting/development.
---

[ABclonal Knowledge Base](https://blog.abclonal.com/blog)

# [Featured Product Weekly: DNA Methyltransferase Antibody](https://blog.abclonal.com/blog/featured-product-weekly-dna-methyltransferase-antibody)

 Written by [Panyue (Penny) Hao](https://blog.abclonal.com/blog/author/panyue-penny-hao) | Aug 28, 2018 1:00:00 PM

DNA methyltransferase (DNMT) is an important family of enzymes that catalyze and maintain DNA methylation, a common marker in the epigenetic silencing of target genes. The enzymes play a key role in the regulation of gene expression and genomic imprinting/development.

Three groups of DNMTs have been found in mammals:  
1. DNMT1 - A key enzyme in DNA replication and the maintenance of DNA methylation.  
2. DNMT2 - Highly conserved between species, this DNMT mainly acts as a transfer RNA (tRNA) methyltransferase, through the methylation of specific residues in the anticodon.   
3. DNMT3 - Contains three subunits: 3A and 3B are [de novo DNA methyltransferases](https://en.wikipedia.org/wiki/DNA_methyltransferase#De_novo_vs._maintenance), and 3L is a regulatory protein that plays a role in embryonic development, gene imprinting, and chromosome inactivation.

DNMT1, DNMT3A and DNMT3B form a protein complex that interacts with histone deacetylases (such as HDAC1, HDAC2, Sin3A), transcriptional repressors (examples include RB and TAZ-1), and heterochromatin-associated proteins (HP1, SUV39H1) to promote gene silencing and maintain normal levels of DNA methylation. DNMT1 is one of the most important and most-studied enzymes in the DNMT family. Numerous studies have found that DNMT1 is involved in the abnormal methylation of DNA, and the occurrence/development of tumors, usually through the silencing of tumor suppressor genes.

To promote [research into epigenetics](https://abclonal.com/epigenetics-nuclear-signaling/), ABclonal Technology offers a wide range of DNMT-specific antibodies, as well as other factors that are involved in the [epigenetic writing and erasing of core histones](https://abclonal.com/Researcharea/antibodies/?research=Epigenetic_writers_and_erasers_of_core_Histones&catid=733).

 

## DNMT1 Polyclonal Antibody

<https://abclonal.com/catalog-antibodies/DNMT1PolyclonalAntibody/A16729>

## DNMT3A Polyclonal Antibody

<https://abclonal.com/catalog-antibodies/epi/DNMT3APolyclonalAntibody/A3169>

 

<https://abclonal.com/catalog-antibodies/DiMethyl-DNMT3A-K44pAb/A16012>

 

## DNMT3L Polyclonal Antibody

<https://abclonal.com/catalog-antibodies/DNMT3LPolyclonalAntibody/A13591>

[View full post](https://blog.abclonal.com/blog/featured-product-weekly-dna-methyltransferase-antibody)

```json
{
  "@context" : "http://schema.org",
  "@type" : "BlogPosting",
  "author" : {
    "@type" : "Person",
    "name" : "Panyue (Penny) Hao"
  },
  "dateModified" : "2022-06-23T17:11:30.065Z",
  "datePublished" : "2018-08-28T13:00:00Z",
  "headline" : "Featured Product Weekly: DNA Methyltransferase Antibody",
  "image" : {
    "@type" : "ImageObject",
    "height" : 626,
    "url" : "https://info.abclonal.com/hubfs/DNA%20Methyltransferase-01.png",
    "width" : 835
  },
  "mainEntityOfPage" : "https://blog.abclonal.com/blog/featured-product-weekly-dna-methyltransferase-antibody",
  "publisher" : {
    "@type" : "Organization",
    "logo" : {
      "@type" : "ImageObject",
      "height" : 60,
      "url" : "/hs/hsstatic/content_shared_assets/static-1.4092/img/default-amp-logo.png",
      "width" : 60
    },
    "name" : "Blog"
  }
}
```