CREB1 is a basic leucine zipper domain (bZIP) transcription factor that activates a target gene through a cAMP response element. As a key transcriptional regulator, CREB1 plays a role in a variety of cellular responses by mediating a number of physiological stimuli. CREB1 is expressed in many tissues and plays an especially important regulatory role in the nervous system by promoting neuronal survival, driving precursor proliferation, neurite outgrowth, neuronal differentiation and more. In addition, CREB1 signaling is involved in the learning and memory functions of many organisms. CREB1 is capable of selectively activating many downstream genes through interaction with multiple dimerization partners. Phosphorylation of CREB1 at the serine 133 site involves multiple signaling pathways, such as Erk, calcium flux (Ca2+), and stress signaling. Some of the kinases involved in CREB1 phosphorylation include p90RSK, MSK, CaMKIV, and MAPKAPK-2.
ABclonal's CREB1 polyclonal antibody has recently been featured in Nature Communications. In this study, a group from China had previously showed the role of USP24, a ubiquitin peptidase, in cancer progression. The CREB1 antibody was used to delineate the mechanism of IL-6 expression mediated by USP24. ABclonal is proud to have contributed to this addition to the scientific knowledge base, and hope that you will also find good use for this antibody and other products to study epigenetic regulation.
Our ready-made antibody duo products include a pan-specific antibody as well as the phospho-specific antibody targeting the modification site of interest!