CREB1 is a bZIP transcription factor that activates a target gene through a cAMP response element. It regulates a variety of cellular responses by mediating a number of physiological stimuli. CREB1 is expressed in many tissues and plays an especially important regulatory role in the nervous system: promoting neuronal survival, precursor proliferation, neurite outgrowth, neuronal differentiation and more. In addition, CREB1 signaling is involved in the learning and memory of many organisms. CREB1 is capable of selectively activating many downstream genes through interaction with multiple dimerization partners. Phosphorylation of CREB1 at the Ser133 site involves multiple signaling pathways, such as Erk, Ca2+, and stress signaling. Some of the kinases involved in CREB1 phosphorylation include p90RSK, MSK, CaMKIV, and MAPKAPK-2.
CREB1 Polyclonal Antibody
ABclonal's CREB1 polyclonal antibody has recently been featured in Nature Communications.
Phosphorylated Antibody Duo
P90RSK Polyclonal Antibody