CREB1 Antibody: Featured in Nature Communications

Panyue (Penny) Hao

Panyue (Penny) Hao
Oct 16, 2018 10:18:32 AM

CREB1 is a basic leucine zipper domain (bZIP) transcription factor that activates a target gene through a cAMP response element. As a key transcriptional regulator, CREB1 plays a role in a variety of cellular responses by mediating a number of physiological stimuli. CREB1 is expressed in many tissues and plays an especially important regulatory role in the nervous system by promoting neuronal survival, driving precursor proliferation, neurite outgrowth, neuronal differentiation and more. In addition, CREB1 signaling is involved in the learning and memory functions of many organisms. CREB1 is capable of selectively activating many downstream genes through interaction with multiple dimerization partners. Phosphorylation of CREB1 at the serine 133 site involves multiple signaling pathways, such as Erk, calcium flux (Ca2+), and stress signaling. Some of the kinases involved in CREB1 phosphorylation include p90RSK, MSK, CaMKIV, and MAPKAPK-2.

CREB1 Polyclonal Antibody

ABclonal's CREB1 polyclonal antibody has recently been featured in Nature Communications. In this study, a group from China had previously showed the role of USP24, a ubiquitin peptidase, in cancer progression. The CREB1 antibody was used to delineate the mechanism of IL-6 expression mediated by USP24. ABclonal is proud to have contributed to this addition to the scientific knowledge base, and hope that you will also find good use for this antibody and other products to study epigenetic regulation

CREB1 Antibody-1

CREB1 Antibody 2nature communications

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Phosphorylated Antibody Duo

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RK04087_Pho-CREB1-S133-pAb-duoPho-CREB1-S133 Antibody

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P90RSK Polyclonal Antibody

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Panyue (Penny) Hao

Panyue (Penny) Hao

Content creator, knowledge craver, all-around food fanatic thriving to survive in the fascinating yet uncharted world of biology.