Featured Product Weekly: MAPK/ERK Pathway Antibody

Panyue (Penny) Hao

Panyue (Penny) Hao
Sep 4, 2018 6:05:05 PM

ERK1/2 (MAPK1/MAPK3, p44/42MAPK) are members of the mitogen-activated protein kinase family (MAPKs) that are commonly located in the cytoplasm. They act as catalysts in the phosphorylation of serine/threonine and are negatively regulated by the bispecific (Thr/Tyr) MAPK phosphatase family (called DUSP or MKP) and MEK inhibitors (such as U0126 and PD98059).

When cells are stimulated by mitogens, growth factors, or cytokines, the MAPKKK→MAPKK→MAPK cascade is initiated. MEK1 (MAP2K1) and MEK2 (MAP2K2) will then phosphoprylate the activation cylce residues Thr202/Tyr204 and Thr185/Tyr187 repsectively, which in turn activates ERK1/2. Phosphorylated ERK1/2 transduce signals from cell surface receptors to the nucleus  acting on transcription factors such as p90RSK (RPS6KA1), Elk-1, c-myc, c-fos, c-jun, ATF, and NF-kB – to facilitate the transcription and expression of certain genes that are closely related to cell proliferation and division. Hence, ERK1/2 are important markers in cancer diagnosis and treatment.

Phospho-ERK1/2 Antibody Duo

Phospho ERK1 ERK2

Get Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 Antibody Duo

 

KO-validated MAP2K Antibodies 

 MAP2K1-949456-edited                MAP2K2-908960-edited

Get KO-validated MAP2K1 Antibody          Get KO-validated MAP2K2 Antibody

 

P90RSK Antibody

P90RSK Antibody

Get P90RSK Antibody  Get p-P90RSK-S363 Antibody Duo  Get p-P90RSK-S380 Antibody Duo

Phosphorylated Elk1 Antibody

Phospho ELK1

Get Phosphorylated Elk1 Antibody

NFKB Antibody

NFKB1                        NFKB2

                 Get KO-validated NFKB1 Antibody                             Get NFKB2 Antibody

Tags: Cancer, ABclonal News, Featured Product Weekly, Signaling Pathway

Panyue (Penny) Hao

Panyue (Penny) Hao

Content creator, knowledge craver, all-around food fanatic thriving to survive in the fascinating yet uncharted world of biology.