Having just moved a ludicrous amount of boxes and furniture into various U-Hauls and relocation tubes, I can feel all the literal weight of those decisions in my muscles and bones. Now that I'm back in Chicago, nursing my muscle soreness and the occasional bruise, I'm left thinking about the need for better muscular recovery and repair, which brings us to today's wonderful success story with an ABclonal customer as they added to our knowledge of myoblast differentiation and skeletal muscle development.

Perhaps one of the best things about awareness months, even if they bring focus to maladies and situations that are not always pleasant, is to get people interested to learn about the topic, and if they're interested enough, they'll do something to help out. This is the case with amyotrophic lateral sclerosis, or ALS. Some time back, there was the Ice Bucket Challenge which went viral, involved numerous athletes and celebrities and common people, and raised a ton of money for research and to support the afflicted people around the world. Yet, although I know it is a motor neuron disease and that it has affected famous people like the late brilliant physicist Stephen Hawking and more recently, the respected baseball media personality and fellow UChicago alum Sarah Langs (she's not even that old!), I found that I knew remarkably little about the disease itself. So this May, which is ALS Awareness Month, let's learn a little bit more together.

Parkinson's Disease (PD) remains the second-most common neurodegenerative disorder behind Alzheimer's Disease, and the incidence of patients being diagnosed with PD will only rise as we all get older. With this in mind, much personnel and resources are dedicated to discovering more about this disease and to develop better treatments and management strategies to improve the livelihoods of those afflicted with PD. April is Parkinson's Awareness Month, and this is a perfect time for us not only to raise funds and awareness to help PD patients, but also to learn about how companies like ABclonal can help accelerate the research behind PD onset and progression. Here, we highlight studies using ABclonal products that were published within the past year that add new insights into Parkinson's research.

It is always a thrill and a privilege to share our customers' success stories with you, particularly when they feature ABclonal's products in their research publications. Over the past year, we have seen many citations of our reagents in multiple journals, showcasing the partnership ABclonal maintains as a trusted lab partner across a wide range of disciplines. In this entry, we will highlight some of the catalog and custom antibody products our valued customers used to generate recent publication-quality research that adds to our collective understanding of biology!

I recall having to make hundreds of custom peptides, and even though we used an automated peptide synthesizer rather than doing it by hand like another lab in the building, making a dozen peptides at a time still took hours on the machine and then another couple days for the purification and lyophilization processes. My mentor and I briefly joked about using bacteria and a polycistronic construct to just have the little guys use their ribosomes to do it for us, but the purification process probably would have been impractical. This does make me appreciate the wonders of natural biosynthetic machinery, and I promise there is a point here because we still use animal hosts to initially produce antibodies. Today, let's explore the process by which most commercial and custom antibodies are still produced, including here at ABclonal!

We live now in a polarizing environment where many people can't agree on issues that may seem obvious for the greater good, and part of that is likely due to a mistrust of scientists depending on one's education level and political leanings (probably the most diplomatic way I can phrase this). Science has brought us many wonders, from faster transportation, to lifesaving medicines, to the devices you are using to read this right now. Science also works to continue building our knowledge base, and perhaps one of the greatest examples of this is the banning of leaded gasoline, highlighted in an amazing episode of Cosmos hosted by Neil deGrasse Tyson. Because proper regulation is needed to keep both society and science in check, I thought today we would explore how science works with the law to ensure a brighter future for humanity.