RNA methyltransferases such as METTL3, METTL14, WTAP, and VIR can catalyze the methylation of the N6 position of adenylate (M6A) and demethylases include FTO and ALKBH5.
M6A modification is important in epigenetic transcriptional regulation and is present in many eukaryotes, including humans, mice, zebrafish and even yeast. METTL3 (methyltransferase-like protein 3) and METTL14 (methyltransferase-like protein 14) are two catalytic subunits of the N6 adenine methyltransferase complex. In addition to regulating primary miRNA processing, methylation of adenosine residues also regulates mRNA cleavage, processing, translation efficiency, editing and stability, and correct regulation of circadian clocks, embryonic stem cell self-renewal, immune tolerance, meiosis, fertility in mice, and a variety of responses toward stimuli.
ABclonal Technology carries a variety antibodies that target the key proteins in these research and many has been published in journals such as Cell and Nature Letter.
METTL3 Polyclonal Antibody
METTL14 and KO-validated HNRNPA2B1 Polyclonal Antibodies