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COVID-19 Detection Methods: Nucleic Acid vs. IgM/IgG Antibody Tests

Posted by Dennis Miao on May 7, 2020 6:20:55 PM

There is no doubt that the coronavirus is the hottest topic as of late, having dominated media headlines and having fundamentally changed the way that we live and work. As the outbreak of the coronavirus continues to worsen across the globe, the demand for COVID-19 detection is therefore ever-increasing.

New and Old Techniques to Study Protein-DNA Binding

Posted by Michele Mei on Mar 11, 2019 12:28:22 AM

Proteins known as transcription factors play a crucial role in gene regulation by activating, enhancing, and even silencing a gene’s expression.  Many textbooks and resources compare transcription factors (TFs) to something like an on/off switch for gene transcription. However, it is a bit more complicated than just turning gene expression on or off. Various properties (e.g. binding affinity, specificity, and genetic variance of binding sites) impact the binding of TFs to DNA, thereby altering gene expression. To study transcription and how it is regulated, scientists study TF-DNA interactions on a genome-wide level. 

Key Targets in the Hippo Pathway

Posted by Panyue (Penny) Hao on Jan 15, 2019 12:32:35 PM

The Hippo signal is very conservative in evolution. It regulates organ size and tissue stability by regulating cell proliferation, apoptosis, and stem cell renewal. The core process of Hippo signaling is a kinase tandem process, Mst1/2 and Sav1 form a complex, phosphorylate and activate Lats1/2; Lats1/2 kinase then phosphorylates and inhibits transcriptional coactivators Yap and Taz. Yap and Taz are the most important effectors downstream of the Hippo pathway. Upon dephosphorylation, Yap and Taz translocate to the nucleus and interact with TEAD1-4 or other transcription factors (such as CTGF) to induce gene expression, thereby initiating cell proliferation and inhibiting apoptosis.

Seasons Greetings from ABclonal

Posted by Michele Mei on Dec 25, 2018 6:22:22 PM

High-Dilution GAPDH Monoclonal Antibody

Posted by Panyue (Penny) Hao on Dec 4, 2018 10:35:13 AM

GAPDH is a constitutively expressed housekeeping protein, and GAPDH mRNA levels and protein levels are often used as controls in experiments that quantify target-specific expression changes. Recent studies have elucidated the role of GAPDH in apoptosis, gene expression, and nuclear transport. GAPDH may also play a role in neurodegenerative diseases such as Huntington's disease and Alzheimer's disease. ABclonal GAPDH recombinant rabbit monoclonal antibody is a human-specific antibody with a dilution ratio of 1:2560000.

Golgi Apparatus Markers

Posted by Panyue (Penny) Hao on Nov 6, 2018 12:15:49 PM

We have previously explored the function of organelle markers USO1, GOLGA2, and GOLM1 but not how the corresponding antibodies can be applied in research. Organelle marker antibodies are common tools in cell biology research. They can be used with immunofluorescence technology to observe the morphological structure of organelles and understanding the subcellular localization of proteins. In turn, they help to explore the biological functions/role of organelle proteins in normal or disease models. These markers can also be used in Western blot (WB) experiments examining organelle extracts: as a positive control to determine whether the organelle is successfully extracted.