Tumor Immunology Targets

Panyue (Penny) Hao

Panyue (Penny) Hao
Jul 31, 2019 1:42:45 AM

A healthy immune system requires a series of checkpoints to ensure self tolerance and prevent damage to other tissues during immune response. Binding of costimulatory signal transduction molecules (such as CD28, ICOS, GITR) on T cells to their receptors (such as CD80/CD86, ICOSL, GITRL) on antigen presenting cells (APCs) may contribute to T cell activation. However, in some states, inhibitory signals of T cell activation and response occur during the involvement of T cell receptors. These signals are generated by proteins involved in immune checkpoints (eg, PD-1, CTLA-4, TIM-3, and LAG3). Usually PD-1 and CTLA-4 immunological checkpoint proteins are upregulated in T cells infiltrating tumors and bind to their respective ligands, PD-L1 (ligand B7-H1)/PD-L2 (ligand B7- DC) and CD80/86, and down-regulate T cell responses. Immunological checkpoint ligands are often upregulated in cancer cells as a means of evading immune detection. Therefore, immunotherapy by blocking immunological checkpoint protein activation of anti-tumor immunity has become a popular research subject for cancer therapy.

We also want to highlight CCR8 as a therapeutic target, as it has been shown to be highly expressed in regulatory T cells (Tregs) and associated with various cancers. Ongoing research has shown that targeting or blocking CCR8 has been able to prevent Treg recruitment and activation in tumors, allowing other therapies and the host immune system to clear the invasive tissues. Feel free to contact us for more information, and happy experimenting!



CD80 Polyclonal Antibody, PD1 Polyclonal Antibody, TIM3/HAVCR2 Polyclonal Antibody

A16039 CD80 Polyclonal Antibody          A11973 PD1 Polyclnal Antibody          A2516 TIM3 aka HAVCR2 Polyclonal Antibody

See More                                                                                See More                                                                                See More


KO-validated CD44 Polyclonal Antibody, CD4 Polyclonal Antibody

A12410 CD44 Polyclonal Antibody          A0362 CD4 Polyclonal Antibody

See More                                                            See More

Tags: Antibodies, Featured Product Weekly, Immunology, Immune Checkpoints, Tumor

Panyue (Penny) Hao

Panyue (Penny) Hao

Content creator, knowledge craver, all-around food fanatic thriving to survive in the fascinating yet uncharted world of biology.