--- title: ABclonal Knowledge Base | Gene Regulation description: Gene Regulation | --- [![](https://img.abclonal.com/abclonal/Public/Images/25121homepage-logo.png)](https://blog.abclonal.com/) [\[fa icon="user"\]](https://abclonal.com/user/login) [\[fa icon="shopping-cart"\]](https://abclonal.com/shoppingcart) - [Products & Services](https://abclonal.com/catalog-antibodies?id=1) - [Publications](https://abclonal.com/learning/publications) - [Resources](https://abclonal.com/featured-topics) - [![](https://img.abclonal.com/abclonal/Public/Images/25121homepage-logo.png)](https://abclonal.com) - [Promotion](https://abclonal.com/sales/promos) - [Partnership](https://abclonal.com/partner/partnership) - [Company](https://abclonal.com/company/aboutUs) [\[fa icon="user"\]](https://abclonal.com/user/login) [\[fa icon="shopping-cart"\]](https://abclonal.com/shoppingcart) Blogs This is a search field with an auto-suggest feature attached. - There are no suggestions because the search field is empty. - [![Share on facebook](https://blog.abclonal.com/hs-fs/hubfs/hs_marketplace_assets/modules/Social%20Sharing/79/facebook-color.png?width=24&name=facebook-color.png)](http://www.facebook.com/share.php?u=https://blog.abclonal.com/blog/topic/gene-regulation&utm_medium=social&utm_source=facebook) - [![Share on linkedin](https://blog.abclonal.com/hs-fs/hubfs/hs_marketplace_assets/modules/Social%20Sharing/79/linkedin-color.png?width=24&name=linkedin-color.png)](http://www.linkedin.com/shareArticle?mini=true&url=https://blog.abclonal.com/blog/topic/gene-regulation&utm_medium=social&utm_source=linkedin) - [![Share on twitter](https://blog.abclonal.com/hs-fs/hubfs/hs_marketplace_assets/modules/Social%20Sharing/79/twitter-color.png?width=24&name=twitter-color.png)](https://twitter.com/intent/tweet?original_referer=https://blog.abclonal.com/blog/topic/gene-regulation&utm_medium=social&utm_source=twitter&url=https://blog.abclonal.com/blog/topic/gene-regulation&utm_medium=social&utm_source=twitter&source=tweetbutton&text=) - [![Share on google_plus](https://blog.abclonal.com/hs-fs/hubfs/hs_marketplace_assets/modules/Social%20Sharing/79/google_plus-color.png?width=24&name=google_plus-color.png)](https://plus.google.com/share?url=https://blog.abclonal.com/blog/topic/gene-regulation&utm_medium=social&utm_source=google_plus) [![](https://img.abclonal.com/abclonal/Public/Images/0914shutterstock_07.jpg) WHAT'S HOT IN LIFE](https://blog.abclonal.com/blog/topic/whats-hot) [![](https://img.abclonal.com/abclonal/Public/Images/0914shutterstock_06.jpg) #LABLIFE](https://blog.abclonal.com/blog/topic/lab-life) [![](https://img.abclonal.com/abclonal/Public/Images/0914shutterstock_05.jpg) ABCLONAL](https://blog.abclonal.com/blog/topic/abclonal-news) [![shutterstock_339732323 copy](https://blog.abclonal.com/hubfs/shutterstock_339732323%20copy.jpg)](https://blog.abclonal.com/blog/new-and-old-techniques-to-study-protein-dna-binding) Mar 11, 2019, 12:28:22 AM       by [Michele Mei](https://blog.abclonal.com/blog/author/michele-mei) ## [New and Old Techniques to Study Protein-DNA Binding](https://blog.abclonal.com/blog/new-and-old-techniques-to-study-protein-dna-binding) - [Tweet](https://twitter.com/share) Proteins known as **transcription factors** play a crucial role in gene regulation by activating, enhancing, and even silencing a gene’s expression.  Many textbooks and resources compare transcription factors (TFs) to something like an on/off switch for gene transcription. However, it is a bit more complicated than just turning gene expression on or off. Various properties (e.g. binding affinity, specificity, and genetic variance of binding sites) impact the binding of TFs to DNA, thereby altering gene expression. To study transcription and how it is regulated, scientists study TF-DNA interactions on a genome-wide level.  [Read More](https://blog.abclonal.com/blog/new-and-old-techniques-to-study-protein-dna-binding) --- [![shutterstock_140974390-01](https://blog.abclonal.com/hubfs/shutterstock_140974390-01.png)](https://blog.abclonal.com/blog/chip-grade-ctcf-antibody) Oct 23, 2018, 11:43:50 AM       by [Panyue (Penny) Hao](https://blog.abclonal.com/blog/author/panyue-penny-hao) ## [ChIP-grade CTCF Antibody](https://blog.abclonal.com/blog/chip-grade-ctcf-antibody) - [Tweet](https://twitter.com/share) CTCF (CCCTC Binding Factor) is a highly conserved transcription factor that regulates transcriptional activation, transcriptional repression, insulator function, and imprinted control regions (ICRs). 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