A common experimental strategy in studying the effects of a specific protein in cells or organisms is to remove it. One can determine the physiological outcomes in the absence of that protein to ascertain its relative importance in maintaining normal functions, or in some cases, to note that it is dispensable or redundant and might have a backup within the cell to take up the slack. Some targeted techniques include RNA interference (RNAi) and CRISPR-based gene editing, and in many cases, it is possible to generate knockout cell lines or even organisms, like mice, that cannot express a specific protein. But when those strategies are not feasible for the experiment at hand, what is one to do?

As human beings with trillions of cells, each of which has their associated millions of copies of myriad proteins and other biological molecules, it’s something of a miracle that enough of the molecules bump together at the right times to keep us alive and functional. In addition to our own cells, we also coexist with microscopic neighbors, including various beneficial bacteria, while fending off pathogens like disease-causing bacteria, viruses, protozoans, and fungi. We often consider the bacteria and viruses in most human diseases, which invoke our immune systems to fight them to keep us healthy, but it also makes sense that the fungi can affect us as well, a topic in cancer research that is gaining attention.

As we try to come back to some level of normalcy after a couple of long, stressful years of pandemic, science has been continuing to chug along to improve the human condition. In celebration of this, we had silly achievements that made us laugh, then think, in the form of the Ig Nobel prizes, and this week, the cream of the crop was recognized with the three science Nobel Prizes. We wanted to highlight the Physiology and Medicine prize separately since ABclonal is a bioscience reagents company, but as we said before, every field of science is important to the pursuit of not just biological advancement, but the betterment of all humanity. So while you can also read about the achievements of the Medicine winner, Dr. Svante Pääbo, in the previous entry, here are the science prize winners in all the glory we can give them in this blog space!

I had anticipated that 2022's Nobel Prize might go to something more contemporary, like the RNA-based vaccine technology or even the malaria vaccine, but as is sometimes the case with the Nobel committee, this year they threw us a pleasantly surprising curveball with the prize in Physiology or Medicine. With this award, the Nobel Prize definitely awards someone who gave the greatest benefit to humankind indeed as the recognition was for discoveries that look into the very origins of humanity!

That time of year that we've all been anticipating is here! That's right, the 32nd First Annual Ig Nobel Prize ceremony took place on the evening of Thursday, September 15, and the 2022 winners took their bows and hammed it up in one of the most favorite of scientific gatherings. Alas, the ceremony was online-only due to the COVID-19 pandemic, but that did not take away from the fun and love of science that is expected from this festival of glee that features actual Nobel Prize winners! Without further ado, please read on for the many great, uh, achievements by this year's newest additions to the Ig Nobel ranks. 

The arguably most fun thing about science is when your supervisor tells you to just do Experiment X to test hypothesis, but then they kind of forget to tell you how complicated the techniques are to perform that experiment, not to mention all the optimization you would need to do. I personally have never done a chromatin immunoprecipitation (ChIP), and since I wasn’t in genomics, the most sequencing I ever did was setting up quick reactions for the core facility to tell me that my gene constructs were correctly built. ChIP does sound rather simple when explained in class, but when you read up on the protocols,¹ there are some limitations to what ChIP can do, especially given the large amount of starting material you need for the typical experiment. Luckily, in recent years, scientists have started to use an alternative technique called Cleavage Under Targets and Tagmentation, or CUT&Tag, which ABclonal is pleased to support through our antibody reagents.