I am immensely proud of being an alumnus of the University of California at Berkeley, where I was able to get a world class education and have opportunities to meet with and learn from superb professors, some of whom have since earned Nobel Prizes. Those were some of the most fun years of my life and I also appreciated the beautiful, sprawling campus with lots of fantastic architecture and wide-open green spaces to lounge around on and play catch with my friend every now and then. It is mere coincidence that the day this article published is also Marian Koshland's birthday, and it got me thinking about Koshland Hall, one of the newer (now old, because so am I) buildings when I started college, and which Koshland it was actually named after.

Having worked in a proteomics lab for my PhD dissertation, I had some familiarity with the tools and strategies used to study biology on a systems level. One of the concepts I was always interested in was the ability to just follow a protein's journey throughout the cell, from the time it is translated by the ribosome to its final destination either within an organelle or when it is secreted into the extracellular space. At the time I was finishing up, I wasn't sure that the technology was yet advanced enough to make that a reality, particularly if done within a single cell. But within the past few years, a new era of spatial proteomics has emerged to allow us to observe cell biology in a whole new light.

Just a few short weeks after the highly irreverent yet still important Ig Nobel Ceremony, the science community recognized the cream of its crop with the 2023 Nobel Prizes in the first full week of October. The dates for the official announcements are aligned with their usual order throughout the years, always announcing Physiology and Medicine first, then Physics, then Chemistry. The Nobel Committee will transition toward the Literature and Peace prizes to round out the week before Economics is announced on the following Monday. As usual, these prizes recognize a lifetime of work that has given the greatest benefit to humanity. Click the links to check out some of our picks for greatest Nobel science achievements as well a look at last year's Nobel winners, but here we go for this year's running tally of scientific legend.

I recall a time many moons ago when I first started my graduate journey at Duke. I was doing one of my final rotations before joining a thesis lab, and I was sitting in a lab meeting where the group was discussing a particular surface marker on immune cells. Apparently this marker (long since forgot which one) could be cleaved and the "shedding" effect led to normal immune function. So silly young me who didn't know asked, "So what happens if you can't cleave it?" At that point one of the research professors said, "Well that's a stupid question" but in a way that was more bemused than malicious, as it turns out that was the thesis project for the postdoc in the lab who was training me. Other than the part where I probably should have known that was her entire project for like six years, I had stumbled upon my first "stupid" question that actually led to tangible answers that contributed to our understanding of science. Not that I actually did the work here, mind you, but someone else also asked that question and decided to answer it for themselves. I've long since forgotten the mechanism or the phenotype of the mouse that couldn't shed that marker, but the core memory stuck with me and shaped the way I approached students and education, because while questions might seem dumb, they at least always make you think.

I always look forward to this time of year, even more so sometimes than the actual Nobel Prizes, because I want to see what new insights can be derived from the weird science that, as they say, first makes you laugh, then think. That's right, now we are at the 33rd First Annual Ig Nobel Prizes! Just like last year and the few years before, the Ig Nobel ceremony was conducted virtually while the pandemic is still not quelled to an extent that allowed the organizers (men and women of science, see?) to be comfortable enough to have hundreds of people packed into a raucous arena, so the paper airplane tosses and everything else was pre-taped and released online. This did not take away from the absurdity and the few laugh-out-loud moments that I (and probably hundreds of thousands of science enthusiasts tuning in from around the globe) had during the 90-minute event. I do wonder if some of these might supplant my personal top ten, but maybe not just yet. Now let's see what happened!

Having navigated the worst of a pandemic, it is amazing how just barely over a year since the first reports of SARS-CoV-2, a vaccine was developed. What might not be as well known is that the foundation for the COVID-19 vaccine (and a just-as-rapid quell of the spread, though obviously still be vigilant and take proper precautions) was laid out for decades with the study of mRNA-based vaccines. Although I still masked up regularly until early 2023, I was thrilled to have the opportunity to get the vaccine as soon as it was available in 2021, as my family and I sought to protect ourselves and others through a day or two of aches and nausea. The scientists and technicians at the various companies that conceived of and manufactured the vaccines that have been distributed across the planet are relatively anonymous but should be commended. August being National Immunization Awareness Month, let us learn a bit more about vaccination and the pioneers that offer us important protections that we should not take for granted.