When you consider which of the dozens of biological reagents companies to work with, how can you determine which one is the right fit? There is, of course, a business aspect to making and distributing quality antibody reagents. The source of the antibodies that you rely on for your research will matter in terms of supply consistency, lead time, cost, and the associated services to support your product. 

I will admit that I am not a neuroscientist, having focused my research on immunology and cancer cell biology, but I’ve always been aware of Alzheimer’s Disease and the quest for better treatments and an eventual cure. It is because I am not a neuroscientist that I rely on the word of purported experts in the field who have dedicated their careers to finding these answers. There are various caveats like the level of journal the research is published in, the quality of the images (at least to the naked eye), the number of times the research is cited, and the known reputation of the authors, that help to determine the level of trust one can put into the finding. Yet, we find that some things still might slip through the cracks, and this reminds us that we need to scrutinize data more thoroughly to hold each other accountable and maintain trust in science.

In another life, I taught high school biology and had a lot of fun doing it. I had my students do the Cell City when we worked with organelles in the cell, and once we got to the genetics unit, we did something fun called Dragon Genetics. In this activity, students would pair up (one was the mommy dragon, the other the daddy dragon) and throw “chromosome” sticks to see what traits they would “pass on” to their theoretical dragon baby. The activity is quite simple once students understood basic Mendelian genetics (and some of the non-Mendelian patterns as well), and even my son was able to draw his own dragon baby when I had him be my guinea pig while he was still in elementary school. (Figure 1) There were some amazingly creative dragons adorning my classroom, and I hope you can share the Dragon Genetics activity with any teacher friends as we discuss non-Mendelian traits and disease here. As we celebrate the beautifully-designed experiments by Gregor Mendel that led to the modern study of genetics and genomics, we might also be reminded that patterns of inheritance, like many things in life, are far from binary.

Perhaps we only think of zinc as the extra element in our coins to keep manufacturing costs down, or as that random clip from the Simpsons about a world without zinc. Aside from thinking it is a wacky sounding word (I did look up the etymology and it is rather appropriate!), we just don’t consider zinc as being all that important. Once the pandemic hit, though, I noted that Costco was marketing their zinc supplements a lot more, and after doing some extra research, I bought some to add to my diet.

Open collaboration is important for sustainable science, and every new study or publication, no matter the journal or institution, contributes to a greater understanding of biology, for better or for worse. Dozens of prior discoveries funnel into every new breakthrough, so we need to appreciate the years of painstaking labor and thought that go into every new morsel of knowledge. It is very fulfilling when ABclonal products are part of the fuel that drives these studies in diverse fields of biology. With our ABclonal in Action series, we hope to highlight our products as well as the new insights from our customers all over the globe that will become stepping stones for the next generation of cutting-edge bioscience.

You go through everyday life thanks to the intricate communication and interaction of tissue and organ functions between the trillions of cells in your body. Within those tissues, a non-cellular component exists called the extracellular matrix (ECM). Imagine a structure made of water, proteins, and polysaccharides that helps to give structural support to surrounding cells as a connective tissue. Within the ECM lies a group of enzymes named matrix metalloproteinases (MMPs). As endopeptidases, which are enzymes that break peptide bonds, the main role of MMPs is to break down collagen and other proteins in the ECM, whether in normal tissues or in promoting cancer metastasis. MMPs are divided into collagenases, gelatinases, stromelysins, matrilysins, and membrane-type (MT) MMPs, as well as some other non-classified MMPs.^[1]