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title: ABclonal Knowledge Base | ABclonal News (7)
description: ABclonal News | (7)
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[](https://blog.abclonal.com/blog/featured-product-weekly-golgi-protein-antibody)
Aug 7, 2018, 7:24:21 PM by [Panyue (Penny) Hao](https://blog.abclonal.com/blog/author/panyue-penny-hao)
## [Featured Product Weekly: Golgi Protein Antibody](https://blog.abclonal.com/blog/featured-product-weekly-golgi-protein-antibody)
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Although underappreciated, the [Golgi apparatus is indispensable to normal cellular function](https://blog.abclonal.com/blog/traffic-management-the-indispensable-vesicular-transport-system) by ensuring proteins are properly folded and sorted, and to direct diverse functions including [autophagy](https://blog.abclonal.com/blog/abclonal-in-action-updates-and-advances-in-autophagy). Disruptions to proper Golgi function can lead to many disease states, including diabetes, cancer, and neurodegenerative disorders such as Alzheimer's disease.
Part of the Golgi protein family, USO1 protein (also known as vesicle docking protein p115) is a peripheral membrane protein that can be used as a Golgi marker. It cycles between the cytoplasm and the Golgi apparatus during interphase. The position of the USO1 protein is regulated by phosphorylation -- dephosphorylated proteins bind to the Golgi membrane and dissociate from the membrane when phosphorylated. This regulated transportation plays an important role in protein localization, secretion, and signal transduction. USO1 protein acts as a vesicle anchor by interacting with the target membrane and keeping the vesicles close to the target membrane. In addition, the USO1 protein interacts with GOLGA2 (GM130) and Giantin to promote endoplasmic reticulum-Golgi transportation. A large part of Golgi-related research is in understanding how to maintain proper Golgi function to prevent and treat human diseases.
[Read More](https://blog.abclonal.com/blog/featured-product-weekly-golgi-protein-antibody)
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[](https://blog.abclonal.com/blog/featured-product-weekly-aifm1-antibody)
Jul 31, 2018, 12:58:57 PM by [Panyue (Penny) Hao](https://blog.abclonal.com/blog/author/panyue-penny-hao)
## [Featured Product Weekly: AIFM1 Antibody](https://blog.abclonal.com/blog/featured-product-weekly-aifm1-antibody)
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AIFM1, also known as Apoptosis Inducing Factor (AIF), is a widely expressed flavoprotein that plays an important role in caspase-independent apoptosis. AIF normally exists in the mitochondrial intermembrane space.
[Read More](https://blog.abclonal.com/blog/featured-product-weekly-aifm1-antibody)
---
[](https://blog.abclonal.com/blog/weekly-feature-lamin-antibody)
Jul 24, 2018, 11:53:02 AM by [Panyue (Penny) Hao](https://blog.abclonal.com/blog/author/panyue-penny-hao)
## [Featured Product Weekly: Lamin Antibody](https://blog.abclonal.com/blog/weekly-feature-lamin-antibody)
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[Nuclear lamina](https://www.ncbi.nlm.nih.gov/pubmed/12921235) is a layer of cross-linked fibrin network that commonly exists in higher eukaryotic cells. It is interior to the nuclear envelope with a fiber diameter of about 10 nm. The nuclear lamina of higher animals are usually composed of three intermediate filament polypeptides – lamins A, B, and C. The nuclear lamina is closely related to the stability of nuclear envelopes, maintenance of nuclear pore location, stabilizing interphase chromatin morphology and spatial structure, chromatin construction, and nuclear assembly.
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[](https://blog.abclonal.com/blog/weekly-feature-golm1-antibody)
Jul 16, 2018, 11:09:25 AM by [Panyue (Penny) Hao](https://blog.abclonal.com/blog/author/panyue-penny-hao)
## [Featured Product Weekly: GOLM1 Antibody](https://blog.abclonal.com/blog/weekly-feature-golm1-antibody)
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Golgi membrane protein 1 (GOLM1) is a type II Golgi membrane protein discovered in recent years. Although underappreciated, the [Golgi apparatus is indispensable to normal cellular function](https://blog.abclonal.com/blog/traffic-management-the-indispensable-vesicular-transport-system) by ensuring proteins are properly folded and sorted, and to direct diverse functions including [autophagy](https://blog.abclonal.com/blog/abclonal-in-action-updates-and-advances-in-autophagy). Disruptions to proper Golgi function can lead to many disease states, including diabetes, cancer, and neurodegenerative disorders such as Alzheimer's disease. GOLM1 is a key protein in ensuring that proteins taken in from the endoplasmic reticulum are properly transported to their final destination in and out of the cell, and also may be involved in responses to viral infection.
The GOLM1 protein expression level increases in a variety of diseases and cancerous tissues. It is especially closely related to liver diseases. Many studies have shown that GOLM1 is more sensitive and more specific than alpha-fetoprotein (AFP, the most specific marker for primary liver cancer and the main indicator for the diagnosis of liver cancer) in the serological diagnosis of liver cancer. GOLM1 is expected to be the serological marker for the early diagnosis of liver cancer. It has also been reported to be highly expressed in patients with viral hepatitis and cirrhosis. The study of GOLM1 and other Golgi markers remains crucial to our understanding of human disease, and offers new avenues to develop more effective targeted therapies to alleviate the burdens of these ailments.
[Read More](https://blog.abclonal.com/blog/weekly-feature-golm1-antibody)
---
[](https://blog.abclonal.com/blog/abclonal-technology-at-biotech-japan)
Jul 15, 2018, 9:21:13 PM by [Panyue (Penny) Hao](https://blog.abclonal.com/blog/author/panyue-penny-hao)
## [ABclonal Technology at BIOtech Japan 2018](https://blog.abclonal.com/blog/abclonal-technology-at-biotech-japan)
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Last week, ABclonal Technology set foot on the "Land of the Rising Sun" to attend the 17th International Biotech and Life Sciences Exhibition & Conference. One of our technical sales specialists from the Boston office, Giovanni Musto, joined our colleagues in Japan for the exhibition. Here are some highlights from his trip.
[Read More](https://blog.abclonal.com/blog/abclonal-technology-at-biotech-japan)
---
[](https://blog.abclonal.com/blog/abclonal-technology-x-immunology-2018)
May 21, 2018, 12:13:45 PM by [Panyue (Penny) Hao](https://blog.abclonal.com/blog/author/panyue-penny-hao)
## [ABclonal Technology x Immunology 2018](https://blog.abclonal.com/blog/abclonal-technology-x-immunology-2018)
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During the passed weekend, ABclonal Technology had the honor to join esteemed immunologists around the world for the Immunology 2018 conference held in Austin, Texas (go Longhorns). Let's check out some of the highlights.
[Read More](https://blog.abclonal.com/blog/abclonal-technology-x-immunology-2018)
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